Our Services

Pharmacokinetic and Toxicokinetic Modeling

Turning Bioanalytical Data into Insight for Smarter Decision-Making


At VJO Canada, we provide in-house pharmacokinetic (PK) and toxicokinetic (TK) modeling services to support informed, data-driven decisions throughout the drug development lifecycle. From initial animal PK studies to safety toxicokinetics for first-in-human dose prediction to regulatory submissions, our modeling experts deliver scientifically sound, regulatory-aligned insights that accelerate development and reduce risk.

Our PK/TK Services Include:


Non-compartmental analysis to support bioanalytical data:

  • Standard single or multiple dose designs (SAD/MAD), dose proportionality
  • Bioavailability / Bioequivalence
  • Drug accumulation
  • Multiple routes of administration and species
  • Integration of metabolite(s) profile relative to parent drug


  • Toxicokinetic (TK) evaluations to support non-clinical studies:


  • Toxicokinetic analysis to support non-clinical safety and toxicology data:
  • Full range of studies from Maximum Tolerated Dose (MTD) to pivotal GLP subchronic and chronic studies
  • Sparse or full bioanalytical data in a variety of biological fluids


  • Exposure-response relationships and dose optimization


  • PK bridging strategies for global development


  • PK study design consultation and protocol support


  • Regulatory-ready reports for IND, CTA, NDA, and BLA submissions


FDA 21 CFR Part 11 Compliant System



All analyses and data handling are conducted within FDA 21 CFR Part 11-compliant validated systems, ensuring full traceability, data integrity, and regulatory readiness for electronic submissions.



ADME Insight & Integration


We provide support in absorption, distribution, metabolism, and excretion (ADME) assessment to help characterize drug behavior and ensure data is appropriately interpreted within the context of safety and efficacy. Our team works closely with bioanalytical experts to integrate ADME findings with PK/TK data for comprehensive development insight.



Why VJO Canada?


Our PK/TK experts combine pharmacological depth with regulatory know-how, giving sponsors the scientific clarity and confidence they need for critical milestones. Whether you're designing first-in-human trials or addressing agency questions, our modeling support ensures you're ready every step of the way.